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Regulation of voltage-gated sodium channel expression in mouse midbrain dopamine neurons.
The voltage-gated sodium channels, Na(v)1.1-Na(v)1.8, are required for action potential firing in the midbrain dopamine neurons of the substantia nigra. In the present study, it was hypothesized that the expression of voltage-gated sodium channels in the mouse midbrain dopaminergic neurons of the substantia nigra, pars compacta (SNc), might be regulated by neuromodulators. A quantitative reverse-transcription polymerase chain reaction (RT-PCR) assay was used to investigate the effect of the neuromodulators, dopamine and N-methyl-D-aspartate (NMDA), on the expression of the mRNAs encoding the voltage-gated sodium channels, Na(v)1.1, Na(v)1.2, and Na(v)1.6, in the SNc. Functional analysis was performed using whole-cell recordings to measure sodium currents. RT-PCR and whole-cell recording experiments demonstrated that the expression of all three sodium channel mRNAs was down-regulated by dopamine and up-regulated by NMDA. The functional properties of the sodium channels in SNc neurons were not altered by the application of dopamine and NMDA. The present results indicate that the expression of voltage-gated sodium channels in SNc neurons is regulated by neuromodulators. These findings may help to clarify the mechanisms of the actions of dopamine and glutamate on dopamine neurons in the SNc.Q:
How can I rename an image field and add a modal view to a view?
I have been tasked with renaming an image field in the view of a content type, and adding a modal view to that content type.
Essentially, I need to add a file upload field, along with a view that allows for additional information about the image. Is it possible to do this all in one module, or is this possible only if done in 2 or more separate modules?
You can do it with one module. I have done this before where I did the following.
Created a form element in my form.element.inc.php
Added a form renderer to the form.renderer.inc.php
Added a view to the view.module
Added the form element and the renderer to the view, added
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Create variable names with for loop, concatenate them all together
I want to be able to take a name and each letter of the name and add them all together in order. I understand how to do the “equal sign” part, but not the “add each letter with for loop” part. I have the following but it throws an error.
Here is my code:
name = input(“enter the name”)
total = 0
for letter in word: