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…Dopamine D3 receptors, cholesterol metabolism, and function of blood-brain barrier in hyperdopaminergic mice.
At the brain level, dopamine is associated with energy metabolism and neuroendocrine regulation. In particular, dopamine D3 receptors are involved in the regulation of energy metabolism and represent a link between dopamine D2 and D1 receptors. We have previously demonstrated that dopamine D3 receptor agonists impair the integrity of blood-brain barrier (BBB) in the mouse brain. We thus postulated that brain cholesterol metabolism and BBB function are linked to dopamine D3 receptor stimulation. We then measured cholesterol in the choroid plexus, corpus callosum, and hippocampus of dysmature, hyperdopaminergic mice (+/- 1.8-fold increase of tyrosine hydroxylase activity) and their controls (+/- 1.5-fold increase of tyrosine hydroxylase activity), treated with quinpirole (a dopamine D3 receptor agonist). We found lower cholesterol levels in the choroid plexus and corpus callosum of dysmature mice but higher levels in the hippocampus. Inhibition of cholesterol synthesis but not uptake lowered the cholesterol levels in the choroid plexus and corpus callosum but had no effect on the hippocampus. Inhibition of cholesterol efflux but not uptake lowered the cholesterol levels in the choroid plexus, hippocampus, and corpus callosum. These findings show that the degradation of cholesterol in the choroid plexus and corpus callosum but not in the hippocampus is linked to D3 receptor stimulation in dysmature mice. Thus, we suggest that hyperdopaminergic mice could present altered brain cholesterol metabolism.The present invention relates to means for vacuum suctioning paint pans used to paint boats. The means can be used to remove overflow paint from the boat paint pan during clean out of the paint pans.
In the prior art, means for removing overflow paint from paint pans have included vacuum pads of cloth material which are detachably connectable to a vacuum tube. The vacuum tube is connected to a power source having a suction line connectable to the vacuum tube. A frame for the paint pan is detachably connected to the vacuum tube. The vacuum tube is clamped between the frame for the paint pan and a support for the paint pan. This frame has a detachable connection to the vacuum tube and the detachable